Lipo 360 involves liposuction of the entire body to eliminate all concerned areas of fat deposition. This means that most patients will require circumferential body contouring with coverage of over 50 % of their body surface area. Liposuction involves traversing this large area with hollow bore cannulas that rip out fat cells from amongst ligaments, blood vessels, and nerves. In doing so, the small microvessels that cover the body like a net called the horizontal plexus are irritated and made raw. As such, these microvessels will leak plasma, red blood cells, and pro-inflammatory cells from physical micro-tears in the vessel walls. If this physical trauma is compounded by drugs that induce dilation of vessels, deleterious leakage of blood contents will occur.
Unfortunately, marijuana smoking can harm lipo 360 since it is a strong vessel dilating agent, a vasodilator. You might be wondering why Marijuana would be considered a vasodilator. The first notion that Marijuana is a vasodilator is the observation that potheads always get red-eye. The red-eye is caused by the dilation of blood vessels in the eye. This effect of Marijuana is useful in the treatment of glaucoma where increase blood pressure in the eye can be released by leaky retinal vessels following the smoking of marijuana. However, this same beneficial effect of marijuana in the eyes can have a deleterious effect on lipo 360 patients.
Mechanism of marijuana vasodilating
The active ingredient in marijuana is a cannabinoid, a chemical compound that first elevates your blood pressure and heart rate. These effects added to cannabinoids vasodilating effects can have a deleterious effect on lipo 360 patients with the adverse effect of plasma, red blood cells, and pro-inflammatory cells being pushed out of vessels into the soft tissues. The mechanism for vasodilatory effects has been studied in eye, brain, and heart organs. Several studies have documented the effects of cannabinoid 2-arachidonoylglycerol, a metabolic byproduct, on pericytes that seal the junctions between endothelial cells that line the inside of the blood vessels. Pericytes are involved in controlling the in and outflow of plasma and cells from inside to outside the vessels. The above chemical has been demonstrated to shorten the width of the pericytes thus making vessels leaky. As such, the combination of increased blood pressure, increase heart rate, and leaky capillaries result in an undesirable leakage of fluid, red blood cells, and pro-inflammatory cells into the soft tissues.
Deleterious effects of leaking plasma fluid, red blood cells, and pro-inflammatory cells into the soft tissues. The side effect of plasma fluid leakage is significant because liposuction can be associated with adverse fluid shifts. Fluid shifts can have a detrimental effect on your cardiovascular performance. Leakage of red blood cells can be dangerous to your health as you can become anemic. Also, red blood cells will increase your discomfort as they will activate pain sensory nerves. Finally, hemosiderin deposition from red blood cells can cause soft tissue staining and subsequent hyperpigmentation. Finally, pro-inflammatory cells can induce a hyperinflammatory cascade that will result in the influx of fibroblasts that will produce collagen over deposition. Over deposition of collagen molecules can result in undesirable scar tissue formation and an undesirable firmness of the tissues.